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Simulated models of TACSs. ( A1 ) The wavy, unorganized <t>ECM</t> pattern of TACS-1 from <t>a</t> <t>histology</t> of normal mammary tissue. ( A2 ) Simulated ECM with randomly aligned fibrils as a model of TACS-1. ( B1 ) ECM patterns of TACS-2 encircling the cell cluster. ( B2 ) Simulated ECM with fibrils aligned parallel to the cell cluster as a model of TACS-2. ( C1 ) ECM pattern of TACS-3 aligned near the invading cells; ( C2 ) Simulated ECM with fibrils pointing radially outward from the tumor at the side of the invasion; model of TACS-3. The increased fibril stiffness is indicated by darker colors.
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Simulated models of TACSs. ( A1 ) The wavy, unorganized <t>ECM</t> pattern of TACS-1 from <t>a</t> <t>histology</t> of normal mammary tissue. ( A2 ) Simulated ECM with randomly aligned fibrils as a model of TACS-1. ( B1 ) ECM patterns of TACS-2 encircling the cell cluster. ( B2 ) Simulated ECM with fibrils aligned parallel to the cell cluster as a model of TACS-2. ( C1 ) ECM pattern of TACS-3 aligned near the invading cells; ( C2 ) Simulated ECM with fibrils pointing radially outward from the tumor at the side of the invasion; model of TACS-3. The increased fibril stiffness is indicated by darker colors.
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Image Search Results


Simulated models of TACSs. ( A1 ) The wavy, unorganized ECM pattern of TACS-1 from a histology of normal mammary tissue. ( A2 ) Simulated ECM with randomly aligned fibrils as a model of TACS-1. ( B1 ) ECM patterns of TACS-2 encircling the cell cluster. ( B2 ) Simulated ECM with fibrils aligned parallel to the cell cluster as a model of TACS-2. ( C1 ) ECM pattern of TACS-3 aligned near the invading cells; ( C2 ) Simulated ECM with fibrils pointing radially outward from the tumor at the side of the invasion; model of TACS-3. The increased fibril stiffness is indicated by darker colors.

Journal: Cells

Article Title: Dynamics of Fibril Collagen Remodeling by Tumor Cells: A Model of Tumor-Associated Collagen Signatures

doi: 10.3390/cells12232688

Figure Lengend Snippet: Simulated models of TACSs. ( A1 ) The wavy, unorganized ECM pattern of TACS-1 from a histology of normal mammary tissue. ( A2 ) Simulated ECM with randomly aligned fibrils as a model of TACS-1. ( B1 ) ECM patterns of TACS-2 encircling the cell cluster. ( B2 ) Simulated ECM with fibrils aligned parallel to the cell cluster as a model of TACS-2. ( C1 ) ECM pattern of TACS-3 aligned near the invading cells; ( C2 ) Simulated ECM with fibrils pointing radially outward from the tumor at the side of the invasion; model of TACS-3. The increased fibril stiffness is indicated by darker colors.

Article Snippet: Here, we present a novel multi-cellular lattice-free ( MultiCell-LF ) agent-based model of ECM that, in contrast to static histology images, can simulate dynamic changes between TACSs.

Techniques: